• Over 99% pure
• Independently lab tested
• No additives, binders or fillers
  
• Gluten-free, vegan and allergy friendly

About Our Resveratrol Supplements:

Resveratrol is a naturally occurring compound and is a polyphenol which is present in a number of common food items such as berries, grapes, vine, peanuts, etc. Plants that produce resveratrol do so partly as a protective mechanism and response to stressors within their environments, including the presence of insects or other predators, damage, injury, and fungal varieties. Resveratrol is believed to be one of the most potent polyphenols.

The properties of resveratrol were first discovered when researchers established that a variety of yeasts, microbes, insects and animals that were fed resveratrol experienced an increased lifespan. Several studies continued to confirm these properties in their successful work on flies, fish, mice and nematode worms, all of which lived longer compared to control groups that were not treated with this phytonutrients.

How Does Resveratrol Supplement Work?

Resveratrol supplements can either passively cross cell membranes or interact with its receptors due to its unique physical and chemical properties, making it possible for Resveratrol to interact with inter and extracellular molecules effortlessly. It is because of this that its mechanism of action is triggered by one of the two means (at a cellular level):

• By developing its effect inside the nucleus
• Activating intracellular mechanism by first activating signalled pathways when binding to receptors of the cell membrane

The way it potentially functions as a longevity-promoting substance can possibly be explained by how it activates SIRT. A study suggests that it can directly activate the NMNAT enzyme, which increases the intracellular activity and levels of NAD+, which is likely to affect SIRT, which primarily requires the presence of NAD+ in order to function. In another experiment, human cells were treated with Resveratrol independent of NMNAT enzyme. Even without the presence of NMNAT, Resveratrol still rejuvenated old cells, which started to divide and develop longer telomeres with the restoration of the splicing factor expression. The cells not only started to appear younger but behaved more like younger cells as well.

Benefits of Resveratrol

The benefits of resveratrol are robust, thanks to its potential roles as a longevity agent and heart health supporter. It is thought to improve blood flow and reduce cholesterol levels, contributing to cardiovascular advantages. Resveratrol's anti-inflammatory properties can also help manage chronic inflammation, further emphasising its potential as part of a comprehensive wellness regime.

Additionally, resveratrol is being explored as a compound that supports brain health, with some studies suggesting it could offer protective benefits against cognitive decline.

How Much Resveratrol Should You Take?

Understanding the correct dosage of our resveratrol supplement is essential for maximising its benefits while minimising any potential side effects. The suggested daily serving ranges from 500 mg, to 1,000 mg.

Multiple studies have observed that Resveratrol’s bioavailability can be improved when consumed with a food that has an element of fat content. This observation is in alignment with Professor David Sinclair’s approach, which is to take Resveratrol with yoghurt at breakfast. This paper explores the various studies on intake options. Other studies, also included in the aforementioned paper, have indicated that taking Resveratrol with green tea will enhance its effects and that it is best taken on an empty stomach.

Does Resveratrol Fit Into a Vegan Diet?

For those following a vegan diet, trans resveratrol supplements offer a plant-based option to bolster nutritional intake without animal-derived ingredients. Our trans-resveratrol come in vegan-friendly capsules, using cellulose for the capsule shell instead of gelatin, and are free from animal products.

This supplement can effectively complement other vegan supplements like magnesium, vitamin B12, or vitamin D to provide comprehensive dietary support.

Resveratrol in the UK: Where to Find and What to Expect?

Resveratrol supplements are widely available in the UK, both online and in health food stores. Consumers should seek products where each batch is independently tested for quality and purity, ensuring they are free from unnecessary additives or fillers.

Reading customer reviews can provide insights into the effectiveness and quality of specific products, helping buyers make informed choices.

References and Further Readings:

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

• https://pubmed.ncbi.nlm.nih.gov/12939617/

Howitz, K.T., Bitterman, K.J., Cohen, H.Y., Lamming, D.W., Lavu, S., Wood, J.G., Zipkin, R.E., Chung, P., Kisielewski, A., Zhang, L.L. and Scherer, B., 2003. Nature, 425(6954), pp.191-196.

Concentration of the Phytoalexin Resveratrol in Wine

• https://www.ajevonline.org/content/43/1/49

Siemann, E.H. and Creasy, L.L., 1992.  American Journal of Enology and Viticulture, 43(1), pp.49-52.

Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans

• https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090131

Blanchard, O.L., Friesenhahn, G., Javors, M.A. and Smoliga, J.M., 2014. PloS one, 9(2), p.e90131.

Caloric restriction mimetics slow aging of neuromuscular synapses and muscle fibers

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963347/

Stockinger, J., Maxwell, N., Shapiro, D., deCabo, R. and Valdez, G., 2018. The Journals of Gerontology: Series A, 73(1), pp.21-28.

Calorie restriction-like effects of 30 days of resveratrol UK supplementation on energy metabolism and metabolic profile in obese humans

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880862/

Timmers, S., Konings, E., Bilet, L., Houtkooper, R.H., van de Weijer, T., Goossens, G.H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S. and Moonen-Kornips, E., 2011.  Cell metabolism, 14(5), pp.612-622.